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Coetzee T., Suzuki K., Nave K.A., Popko B. The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein … Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids. We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain. To develop better treatment for these diseases, we must understand the mechanisms involved in myelination. Myelin is a specialized structure with distinct lipid and protein constituents. Galactosylceramide (GalCer) and sulfatide make up approximately 30% of total myelin lipids, and more than half of these galactolipids contain fatty acid with a hydroxyl group at the C2 position (2-OH … Galactolipid synthesis was measured through enzyme activity and real‐time mRNA expression analyses. Based on the findings, myelination and white matter integrity were studied by immunohistochemistry, stereological methods, electron microscopy and magnetic resonance imaging.

Search 17 grants MYELIN is the most stable membrane known and the fact that it contains ten times as much long chain sphingolipid as any other known membrane structure has led to the suggestion that the long chain fatty acids (> 18 carbon atoms) in these sphingolipids are concerned in the stability of myelin^1,2. The finding^3,4 of a myelin deficient mouse mutant whose galactolipids and Despite the extraordinary abundance of 2-OH galactolipids in myelin, there is surprisingly little understanding of the basic biochemistry and physiological role of 2-OH galactolipids. The overall goal of this study is to elucidate the pathway for myelin 2-OH lipids and their roles in myelination, myelin function, and cell signaling. Abstract: The developmental lipid profiles in the human cerebrum, cerebellum and brain stem are presented, with special reference to galactolipids as myelin markers to trace myelination in the three main parts of the human CNS. A group of undernourished children were also studied to test the vulnerability of myelinogenesis in the different regions of the human brain.

3 and 4) show very similar developmental profiles in the forebrain as well as in the cerebellum, indicating their value as myelin markers.

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The fatty acid compositions of galactolipids in neonatal mouse brain gradually changed during the course of myelination. The relative ratio of 2-hydroxy versus nonhydroxy galactolipids was very low at 2 days of age (∼8% of total galactolipids) and increased 6- to 8-fold by 30 days of age.

LUP publications 2008

(1994).

Minskar testosteronhalten och myelinlagret Det innebär att testosteronet deltar i att reaktionstiden hos hingstens nerver är snabbare på grund av tjockare myelin.
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The single-mutant mice produce abnormal myelin containing similar ultrastructural abnormalities, suggesting that Epigenetic control of Myelination in PNS Review Review Molecular mechanisms regulating myelination in the peripheral nervous system Jorge A. Pereira, Fre´de´ric Lebrun-Julien and Ueli Suter Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Zu¨ rich, CH-8093 Zu¨ rich, Switzerland Glial cells and neurons are engaged in a continuous and highly Astrocytes, Implications for Myelination and Remyelination Veronica T. Cheli1, J. Correale2, Pablo M. Paez1 and Juana M. Pasquini3 Abstract Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron … The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin. Recent studies have found that mice lacking either the galactolipids or PLP are able to form myelin sheaths with apparently normal periodicity and near normal compaction. 2002-12-19 · The galactolipids also appear to facilitate the maturation of both oligodendrocytes and myelinated fibers, suggesting that they process developmental signals during myelination. These specialized glycolipids are also necessary for the normal development of axo–glial interactions at nodes of Ranvier.

We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain. In this report, we show that FA2H also plays a major Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids. We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain.
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Coetzee T, Suzuki K, Nave KA, Popko B. Myelination in the absence of galactolipids and proteolipid proteins. Mol … bodies raised against GalC inhibit myelination in vitro and in vivo31–34. Although these studies suggest a role for GalC in axoglial interactions, the nature of these interactions remains to be determined. Moreover, at T. Coetzee et al.– Myelin galactolipids REVIEW Fig. 1.

LUP publications 2008

Myelination in the absence of galactolipids and proteolipid proteins. (1994). Myelination in the absence of myelin-associated glycoprotein. (1993). Novel oligodendrocyte transmembrane signaling systems.

Galactolipids are a type of glycolipid whose sugar group is galactose.They differ from glycosphingolipids in that they do not have nitrogen in their composition.. They are the main part of plant membrane lipids where they substitute phospholipids to conserve phosphate for other essential processes. These chloroplast membranes contain a high quantity of monogalactosyldiacylglycerol (MGDG) and Read "Myelin‐Associated Galactolipids in Primary Cultures from Dissociated Fetal Rat Brain: Biosynthesis, Accumulation, and Cell Surface Expression, Journal of Neurochemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.